2276

# of drugs

93

# of cell lines

10

# tissues

445,790

# drug combinations


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Search tissue, study, cell or drug information. 'Advanced search' provides logical operations of multiple search terms.

Advanced

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Total number of drug combinations per tissue. This bar plot will be updated according to the searching or selecting results.


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Standardized name of row compound.

DrugA
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Standardized name of column compound.

DrugB
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Cell line in which the drug combination is tested

Cell_line
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CSS is a drug combination sensitivity score that is derived using relative IC_50 and the area under the drug combination dose-response curves.

CSS
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S synergy score is the % inhibition that is more than expected effect when the two drugs are additive at their relative IC_50s.

S
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ZIP synergy score is the % inhibition that is more than expected effect when the two drugs do not potentiate each other based on the Zero Interaction Potency model.

ZIP
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Bliss synergy score is the % inhibition that is more than expected effect when the two drugs act in probabilistic independence based on the Bliss model.

BLISS
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Loewe synergy score is the % inhibition that is more than expected effect when the two drugs are actually the same based on the Loewe model.

LOEWE
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HSA synergy score is the % inhibition that is more than expected as the highest single drug effect based on the Highest Single Agency model.

HSA
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Block_ID is a numerical identifier referring to the screening results of one drug pair tested in all doses in one cancer cell line.

Block_ID
Please Select a Drug Combination from Data Table

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Histogram of CSS scores for the selected drug combination across all the cell lines

CSS distribution for the selected drug combo:
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Histogram of CSS scores for the selected cell line across all the drug combinations

CSS distrubtion for the selected cell line:

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Barplots of CSS and S scores for all the drug combinations in the database, where the CSS and S scores for your selection are highlighted.

CSS-S
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Dose response matrix for your selected drug combination.

% INHIBITION

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Monotherapy dose-response curve for DrugA.

MONOTHERAPY CURVE
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Monotherapy dose-response curve for DrugB.

MONOTHERAPY CURVE
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Synergy landscape in the unit of % inhibition for your selected drug combination, based on ZIP model

% INHIBITION (ZIP)
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Synergy landscape in the unit of % inhibition for your selected drug combination, based on BLISS model

% INHIBITION (BLISS)

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Synergy landscape in the unit of % inhibition for your selected drug combination, based on LOEWE model

% INHIBITION (LOEWE)
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Synergy landscape in the unit of % inhibition for your selected drug combination, based on HSA model

% INHIBITION (HSA)
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Interpretation of the drug combination interaction network provided by STITCH database.

STITCH VIEW


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Chemical structures for the selected drug combinations by PubChem database. Click the CID for more information.

PUBCHEM VIEW


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Predicted drug target interactions for the selected drug combination by ChEMBL database. Click the ChEMBLID for more information.

CHEMBL VIEW

CHEMBID_1
molecule_chembl_id probability target_accession target_chembl_id value
CHEMBID_2
molecule_chembl_id probability target_accession target_chembl_id value